Comic book movies have been one of the main movers and shakers for comic book values and record sales prices for over a decade.  The earlier you know or can make an educated guess about the what movies are in the pipeline and what characters or villains will be featured, the better chance you have of a successful speculation.

Just take a look at recent prices of Avengers #55, first Ultron.

The video below (with Dominic Monaghan of Lost/Lord of the Rings as a bonus) has some great clips and speculation about Marvel movies up to 2021.  Take a look and let the speculation begin.